Some will still end up in the crayfish's stomach, especially at night. I know this because I used to keep my afr guppies with them. But if the tub is big, the guppies reproduction will more than make up for the losses. It is like survival of the fittest. However, you may end up with some of your prized guppies with torn fins sometimes so make sure your best guppies go to a separate tank. That should do it.
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